Both of the English teams are on course to win their groups and advance to the knockout stage. They could face someone in the knockouts.
Barcelona and Lyon are likely to book their spots in the next round of group play.
Group A's Paris St-Germain or Real Madrid will join Wolfsburg in the quarters.
In Group D, will there be a winner to advance to the last eight? There are many people who need what from the final group matches.
Group A was supposed to be difficult for the Women's Super League winners, but they are off to a great start.
The Blues need a point to qualify for their final group game against two-time finalist Paris Saint-Germain.
If Real Madrid fail to beat Paris Saint-Germain on Friday, then they will reach the last eight.
The English side will advance as group winners if they lose to Las Blancas.
The first team to reach the quarter-finals were Wolfsburg, who will face the winner of the match between St Polten and St. Polten.
The winner of that game will join the Germans in the knockouts. If they beat Slavia Czech on December 16th, they will top Group B.
The Czech side is done.
In their opening Group C match, holders and eight-time winners Lyon were thrashed by a score of 6-1, but since then, they have not lost a match.
They need just a point to guarantee their place in the last eight.
There will be a winner-takes-all match between Lyon and Juventus in the final round of Group C games on December 21st.
If they lost to Lyon, they would still progress to the next round.
Group D has Barcelona, Benfica, and a few other teams in the running.
If Barcelona avoid defeat against the Portuguese side on Thursday, they will be through to the next round of the competition.
If they beat Rosengard on the same day, they will join the 2021 winners.
If they lose by less than two goals against Lisbon in their final Group D match, they will advance.