Alzheimer's and Parkinson's disease can be accelerated by tiny droplets in cells, but they can also be a roadblock to the growth of the disease. If they stick to the edge of the droplets, the situation will get worse, but when they are incorporated into the droplets, the situation gets better. The new findings of the chemists from the University of Twente will be published in the journal Science Advances.
Molecules are present in our cells. It has been about a decade now that we know about the small droplets in our cells. The droplets are formed by a chemical process. It's similar to oil in water. The only difference is that these droplets usually contain a complex mix of large molecule that are found in the cell
Our cells would not function without these droplets. They make sure that the molecule can converge. Scientists don't know if cells can control this process or if the droplets have an impact on disease development
It was on the edge.
Alzheimer's disease, Parkinson's disease, and other age-related diseases are caused by the formation of plaques in the brain. The composition of droplets has been shown to determine how quickly disease proteins accumulate in cells. Accumulations occur more quickly when the edge of the droplets is covered with proteins. The process can be slowed down if they are included in the droplets. Evan Spruijt says that nobody knew that the edge of the droplets was so important.
Spruijt says that there are a lot of factors that influence the development of the disease. There is a new addition to this list. We can begin to search for the causes of these diseases now that we know that droplets can play a part.
The work was accurate.
Researchers at Nijmegen focus on droplets. They created their own droplets with different properties in order to mimic the inside state of cells. We're able to map out exactly what's happening because we use a microscope to see exactly where the proteins are and how quickly they accumulate. This is something that cannot be measured in a living cell.
Some scientists think that when it comes to age related diseases, the disease itself forms droplets, which then form plaques. It's not possible that this would happen in a cell's natural state. One major difference between our study and other studies is that we've shown that other droplets affect the build up of these genes. It may seem like a small detail, but it is important.
The researchers will continue to look at ways in which the edge of the droplets can be altered in a way that the disease proteins can't stick to them. A better understanding of the natural function of these droplets could be provided by this.
The biomolecular condensates can both accelerate and suppress aggregation of -synuclein. There is a book titled "Sci Adv.abq6495."
Journal information: Science Advances
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