Gabriel Jesus will miss the rest of Brazil's World Cup campaign with a knee injury and is a doubt for the Premier League restart with Arsenal later this month.
The player came off in the 64th minute after picking up an injury.
Alex Telles, the left-back who hurt his knee in Brazil's final Group G match, has been ruled out of the tournament.
The Brazilian FA said that Alex Telles and Gabriel Jesus underwent tests on Saturday. The injuries on the right knee made it impossible for them to participate in the World Cup in 2022.
Alex Telles and Gabriel Jesus are at the center of a tug of war between their clubs and the Brazilian National Team.
Brazil are worried about the fitness of their star player, who has missed the last two matches with an ankle injury.
The news is a problem for Mikel Arteta's team, who start their campaign on Boxing Day.
Ben White left England's group in the World Cup due to personal reasons, as Jesus did the same.
It has been clear to see that Jesus has an impact on both the team and the community.
Over the summer, many in the squad have spoken about how the Brazilian forward and his teammates brought a winning mentality to City, while Jesus has been the player for the big moment with five goals and six assists in his first 14 games.
Eddie Nketiah would take up the mantle if Jesus were to leave the team. Despite scoring five goals in seven league games at the end of last season, he has struggled to challenge Jesus for a starting spot since the summer.
Nketiah hasn't lost his sharpness but he hasn't found the net in 12 games from the bench.
He played alongside Jesus in a front two on Saturday Night Football and demonstrated his ability to impact games, but the No 9 position is an area where they cannot afford to lose their best players.
The 16th round is confirmed.
The game between Brazil and South Korea will be played at 7pm.
There is a chance of a quarter-Final.
The kick-off is 3pm on December 9.
There is a chance of a semi- final.
The kick-off is 7pm.
The kick-off is 8pm.
Sky Sports will show the kick-off of the Seagulls in the premier league.
Sky Sports will show the kick-off at 7.45pm.
The FA Cup third round kicks off at 8pm.
Sky Sports will show the kick-off of the Spurs game.
Sky Sports will show the Manchester United game at 4.30pm.