Despite the heroics of Luis Suarez, Uruguay went out of the World Cup on goals scored as they finished third in Group H.
The 35-year-old was in tears after the final whistle as he may have been his last international.
The first and second goals were scored by Giorgio de Arrascaeta.
South Korea's win over Portugal was enough to take them through to the next round.
The side from Asia netted four goals in their three games, but the South American team only scored two in their game against the Africans.
After seeing his shot fall into De Arrascaeta's path for the opener, the veteran formerLiverpool forward followed it up with a glorious assist for the second, as the teams met for the first time in 12 years.
There was an early penalty drama when a spot- kick was saved by a player. After reviewing the goalkeeper's foul on Mohammed Kudus, the referee awarded the penalty.
In the build-up to this game, there was a word called revenge.
Asamoah Gyan missed a penalty that would have given the Black Stars avenging the loss from 2010, but they still celebrated.
There was a lot of drama this time around as well.
The news came through of South Korea's comeback against Portugal after they were 2-0 up.
He sat on the bench in disbelief as he was made aware of the result of the other game.
The emotional forward was consoled by Godin on the pitch at the end of the game.
Gyan's failure to convert in 2010 proved to be extremely costly as he should have taken the lead in this case.
Otto Addo's men needed some inspiration in the second period, but were unable to find a way through an obdurate Uruguayan defence as Kudus saw a low drive tipped wide.
Lawrence Ati-Zigi made a great save to keep out Edinson Cavani's goal, and with time running out, they pushed for the winner, but their effort was palmed away by Ati-Zigi.
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