The Green Bay Packers were knocked out of the game by the Philadelphia Eagles.
While Rodgers was out with a side strain, Hurts had a huge game with 157 rushing yards and two touchdown.
The Los Angeles Rams were knocked out of play-off contention when they lost to the Kansas City Chiefs.
The Las Vegas Raiders beat the Seattle Seahawks in overtime, while Tom Brady's team lost in Cleveland.
The San Francisco 49ers defence pitched a shutout against New Orleans as they continued their ominous winning streak, while the Miami Dolphins and the CincinnatiBengals also maintained their winning ways.
Colin Kaepernick did it against the Packers in a 2012 play-off game, but Philadelphia Eagles quarterback Hurts did it against them.
Hurts' running ability has been key to the Eagles holding the best record in the league at 10-1, as he piled up another 157 yards and added two scores in a punishing ground attack that proved too much for the Packers.
Green Bay fought on even though Rodgers left the field in the second half with an oblique injury and back-up Jordan Love threw a late touchdown to cut the gap.
With Rodgers hurt and their play-off chances all but gone, we may see a lot more of Love as Rodgers' eventual successor.
The Kansas City Chiefs beat the Los Angeles Rams 26-10) to move to 9-2 and lead the AFC, and a fifth straight defeat for the banged-up champion means they are now 3-8 with no thoughts of defending their Super Bowl title.
It's the first time in Sean McVay's tenure that the Rams have lost five in a row, and it ties the worst 11-game record of any defending Super Bowl champ.
Despite making it six wins in seven, Patrick Mahomes wasn't happy with the performance of the Chiefs.
"You like the win, but we have a lot to get better at, especially me," said Mahomes, as the Chiefs prepare to face the Cincinnati Bengals next week in a crucial clash in the battle for the top seed.
In a repeat of last year's play-offs, the Cincinnati team that beat the Kansas City team to make last year's Super Bowl held off the Tennessee team 20-16 to win their third game in a row and tie for the lead in the division.
Baltimore lost to Jacksonville 28-27 thanks to a late touchdown and two-point conversion, but the two teams are still in a tie.
The number one overall pick of the 2021 draft has had a slow start to his career, but head coach Doug Pederson showed great confidence in him by going for the win in the end instead of a tie and overtime.
Lawrence led a 75-yard drive inside the final two minutes to score with 12 seconds remaining against one of the league's best defences, and it could be the beginning of him making his name in the NFL.
For the first time in 183 games, the Jags came from seven points or more down in the final minute as they overcame a missed field goal by Tucker.
The San Francisco 49ers haven't allowed a point in 94 minutes after they beat New Orleans 13-0, giving the Saints their first blank in 332 games and almost 21 years.
Four games in a row the Niners have not allowed a point in the second half.
After a fourth straight win, the San Francisco 49ers are 7-4 and top of the NFC West, while the Miami Dolphins won their fifth in a row with a 30-15 victory over the Houston Texans.
Nick Chubb ran for 116 yards and the winning touchdown in overtime to lead the Cleveland Browns to a 23-17 victory over Tom Brady and the New England Revolution.
The New York Jets may have a big decision to make after back-up quarterback Mike White passed for over 300 yards and three touchdown in their win over the Chicago Bears.
With the Jets right in the play-off mix, Robert Saleh has to decide if White gives them the better chance down the stretch than their highly-drafted regular.
Josh Jacobs scored an 86-yard touchdown in overtime to give the Las Vegas Raiders a 40-34 victory over the Seattle Seahawks.
Jacobs had a team-record 229 rushing yards and two scores along with 74 yards receiving, which was the seventh highest in the modern Super Bowl era.
Russell Wilson's Denver misery continued with a 23-10 defeat for his Broncos against the Carolina panthers, while the Los Angeles Clippers got a late touchdown and two-point conversion from Justin Herbert to beat the ArizonaCardinals 25-24.
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