Coronavirus vaccine
A pharmacist prepares the Pfizer-BioNTech vaccine.
Jessica Hill/AP Photo

Scientists worked at a record pace to develop a vaccine for coronaviruses, which has killed over 6 million people. Scientists were about to give out shots to prevent people from getting sick.

In the US, vaccine development goes through a specific set of steps that include exploratory phases, pre-clinical trials, new drug application, four phases of vaccine trials, and thorough vetting from the US Centers of Disease Control and Prevention.

It might not be as effective as hoped, because all of that could take a long time. Because of the severity of the Pandemic, manufacturers and leading scientists have made efforts to shift funding and speed up the process to yield results.

Here is how long it took to develop vaccines for other infectious diseases.

Smallpox vaccine
A teenage boy is vaccinated against smallpox by a school doctor and a county health nurse, Gasport, New York, 15th March 1938.
Harry Chamberlain/FPG/Hulton Archive/Getty Images

The eradication of smallpox through a vaccine is seen as one of the biggest achievements in public health history, but it took a long time.

The Egyptian Empire of the 3rd Century BCE is thought to be where the origin of the vaccine came from. colonization spread the disease around the world. It had a very high mortality rate.

It wasn't until the 1950s that vaccine treatments began to eradicate the disease in some parts of the world, despite the first successful vaccine being created in 1796.

In 1967, a global effort that provided a higher level of vaccine production and needle technology led to the eradication of the disease.

The only disease that has been completely eradicated around the world is smallpox.

black death bubonic plague
People praying for relief from the bubonic plague, circa 1350.
Hulton Archive/Getty Images

One of the world's oldest and most lethal diseases is plague. There is no licensed vaccine at this time.

Millions of people were killed by plague during the Middle Ages, but the disease is still alive and well today. The plague outbreak in Madagascar caused a lot of concern.

Modern antibiotics can be used to treat plague since it's a disease spread bybacteria. Researchers believe that vaccine development is the best way to stop the spread of disease.

During the Vietnam War, a plague vaccine was made in the US in order to inoculate the troops.

17 candidates for vaccine approval, which are undergoing clinical trials and moving toward FDA approval, are on the Plague Vaccine Target Product Profile.

Typhoid Mary
New York, NY- Mary Mallon(1870?-1938), known as "Typhoid Mary". She was the first person identified as a carrier of typhoid bacilli in the United States.
Getty Images

It can be spread through food and water. It is a significant threat to developing nations in Southeast Asia, Africa, and Latin America.

There are two vaccines that can be used to prevent the disease. German scientists began researching the causes of the disease in 1896 after the discovery of the bacterium that caused it.

The first US typhoid vaccine was developed by a US Army doctor. The vaccine became available to the general American public in 1914 after being used for military purposes.

The US does not recommend vaccinations for routine use.

yellow fever vaccination
A nurse prepares a vaccine against yellow fever at an outpatient clinic in Sao Paulo, Brazil, on January 12, 2018.
MIGUEL SCHINCARIOL/AFP via Getty Images

Max Theiler was the first and only scientist to win a prize for the development of a vaccine. The scientific community has praised his efforts to control yellow fever.

By the end of the 19th century, yellow fever was a threat to the world and had caused deadly epidemics for more than 500 years. Early vaccine efforts at the close of the century mistakenly focused on transmission of the disease when it's actually caused by a virus, and little was known about the disease itself.

The Rockefeller Institute thought they had developed the first successful yellow fever vaccine in 1918, but Theiler proved otherwise and the vaccine stopped production.

The first safe and effective yellow fever vaccine was created by Theiler in 1937.

1918 flu in Oakland
Volunteer nurses from the American Red Cross tend to people with the flu in the Oakland Auditorium in Oakland, California, during the influenza pandemic of 1918.
Edward A. "Doc" Rogers

Millions of people have been killed by flu over the years. There was no vaccine or cure for the 1918 flu.

It took decades of research before the first vaccine was approved for use in the US.

Researchers concluded in 1947 that seasonal changes in the composition of the virus rendered existing vaccinations useless.

Multiple new strains of the virus each year are what researchers realized, along with the two main types of the flu. Scientists have to make changes to the vaccine every year.

The seasonal flu vaccine is designed by the WHO using data gathered from the lytic centers to develop a vaccine based on the three strains most likely to circulate.

FILE PHOTO: A boy receives polio vaccine drops, during an anti-polio campaign, in a low-income neighbourhood in Karachi, Pakistan April 9, 2018. REUTERS/Akhtar Soomro
A boy receives polio vaccine drops, during an anti-polio campaign, in a low-income neighborhood in Karachi, Pakistan, on April 9, 2018.
Reuters

Measles, Mumps, and Rubella have caused disease outbreaks that have killed many people. In the 1960's, individual vaccines were developed for each of them, but a decade later, they were combined into one.

Measles was the first of the three to get its own vaccine. In 1971 Maurice Hilleman of the Institute of Therapeutic Research developed a vaccine that would give immunity to all the Viruses.

Hilleman was credited with the creation of the first vaccine for the measles and the first vaccine for the mumps. He used his previous research and a vaccine developed by Stanley Plotkin to create the first successful vaccine.

The CDC says that one dose of the vaccine is 98% effective against measles.

There are two shots of the vaccine that are 98% effective against the two diseases.

Anthrax
A biological technician wearing a Level C PAPR protective suit climbs up a ladder to inspect a decontamination tent covering Smailholm village hall in southern Scotland March 6, 2007. The technician is part of a team who are currently in the process of decontaminating the village hall which was the scene of an Anthrax outbreak in July 2006.
REUTERS/David Moir

The first clinical account of anthrax was recorded in the 17th century.

In the 1800s, a series of studies to determine where the disease came from, how long thebacteria could live, and how the disease was transmitted through animals paved the way for the first attempts at a vaccine.

The Anthrax vaccine that was created in 1937 is still used today in order to reduce the transmission of the disease to humans. People working in animal processing mills in the United States were the first to benefit from the first human vaccine.

The vaccine that prevents the disease in humans today was developed in 1970.

mmr vaccine
A nurse displays vials of measles vaccine at the Orange County Health Department on May 6, 2019 in Orlando, Florida.
NurPhoto/Paul Hennessy via Getty Images

Measles, Mumps, and Rubella have caused disease outbreaks that have killed many people. In the 1960's, individual vaccines were developed for each of them, but a decade later, they were combined into one.

Measles was the first of the three to get its own vaccine. In 1971 Maurice Hilleman of the Institute of Therapeutic Research developed a vaccine that would give immunity to all the Viruses.

Hilleman was credited with the creation of the first vaccine for the measles and the first vaccine for the mumps. He used his previous research and a vaccine developed by Stanley Plotkin to create the first successful vaccine.

The CDC says that one dose of the vaccine is 98% effective against measles.

There are two shots of the vaccine that are 98% effective against the two diseases.

A woman picks up a Pfizer mRNA COVID-19 vaccine dose
Pfizer, along with BioNTech, used breakthrough mRNA technology to create its COVID-19 vaccine. The potential of this new tech could transform science, leaders at the company said.
Vincent Kalut / Photonews via Getty Images

Billions of people around the world went on a world-wide standstill to stop the spread of the COVID-19 virus.

overcrowded hospitals, stressed out health workers, and pressure on officials to create a vaccine to eradicate the Pandemic were all caused by the coronaviruses.

The nation's top disease expert said in front of Congress that a vaccine could be developed by the end of 2020 or in 2021.

The first person in the US to receive the jab outside of clinical trials was a critical care nurse.

"As a minority, I wanted to instill confidence in my people that look like me to say that it is safe, be guided by science, don't be afraid," Lindsay said.

Four vaccines have been greenlit in the US, including Pfizer-BioNTech, Moderna, Johnson & Johnson, and Novavax.

More than 12.97 billion vaccine doses have been administered around the world and in the US.

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