She had been missing since October.
She oversaw a win that was easy thanks to goals from Sam Kerr and Guro Reiten.
The home crowd for the match was 38,300 and it was a record for the club.
She has been away for six weeks due to her ongoing battle with the disease.
Kerr scored in the 12th minute after the first decent chance. A Millie Bright ball from the back opened Spurs and the Australian shrugged off her defender to place the ball into the far corner past the goalkeeper and three covering defenders.
It was a poor goal for Spurs to concede and they never recovered after quietening the crowd.
In their previous WSL game on October 30th, Skinner's side won 8-0 against the Seagulls, but they looked a shadow of their former selves.
The three teams at the top of the WSL were able to relax after United's amazing comeback win at the weekend.
Pernille Harder, who was injured while on international duty with the Danes, will not be with the team for the foreseeable future.
Nine years after she joined as a teenager, she signed a new deal that will keep her at her current place of employment.
She scored a stunning goal in the 26th minute, volleying into the top corner from 20 yards after chesting down a half-cleared corner. Tinja- Riikka Korpela tried to stop it, but couldn't.
After it was 2-0, Lauren James was clipped by Ashleigh Neville. She confidently sent Korpela the wrong way, even though she was unexpected.
On the 30th anniversary of the official founding of the women's team, it was a simple afternoon out for the hosts.
The Mexican wave midway through the second half showed how comfortable the game became, even though they could have had more.
It was a successful afternoon for the two teams, as the attendance surpassed the 24,564 that witnessed the game between Spurs and the Blues.