The UK's first space launch will be hosted by Spaceport Cornwall after it received an operating licence.
Satellites could be sent into space from the site in Newquay, according to the Civil Aviation Authority.
The first mission is expected to take place in the coming weeks.
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The authority said it was in "very advanced stages" with Virgin Orbit on other applications for launch and range licences.
The Cosmic Girl and Virgin Orbit's LauncherOne rocket traveled from California to Spaceport Cornwall.
The rocket will be released from the jumbo jet at 35,000ft over the ocean to the south of Ireland.
The plane will come back to the spaceport and the rocket will take a number of small satellites into space.
The safety, security and environmental aspects of operating a spaceport in the UK have been demonstrated by Spaceport Cornwall.
Ahead of a proposed launch, the authority said it was in "very advanced stages" with Virgin Orbit on other applications.
The issuing of the operating licence was a historic moment in the history of the UK.
He said that they were proud to be playing their part in facilitating the UK's space ambitions.
This is a major milestone in the process of becoming a leading launch nation.
Satellites made in the UK have to be sent to foreign spaceports to be launched.
The head of Spaceport Cornwall said the region would support the UK industry in using the power of space to benefit life on earth.
She said that the regulatory environment created by the Civil Aviation Authority ensured that the UK launch would set the global bar.
"Virgin Orbit's planned launch reinforces our position as a leading space nation as we look to the future of spaceflight which can spur growth and innovation across the sector, as well as creating thousands of jobs and apprenticeships", said MarkHarper.
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