The biggest rocket in Nasa's history was launched from Florida.
The Artemis vehicle was powered by a combination of light and sound.
An astronauts capsule is to be thrown in the direction of the moon.
If everything goes according to plan, people will climb aboard for future missions to the moon if everything goes well.
There were two aborted launches in August and September because of technical problems.
The Space Launch System was given the "go" to begin its ascent from the Kennedy Space Center at 01:47 local time.
The rocket has a number of important maneuvers to perform high above the planet to get the capsule to the moon.
After lift-off, we don't know if the tasks have been completed correctly.
The last time humans walked on the Moon was 50 years ago.
Artemis is the twin sister of Apollo.
It's planning a series of more complex missions over the next decade that should result in a more sustained presence at Earth's satellite, with the presence of surface habitats and the use of rovers.
It is being sent on a 26 day excursion that will take it into a retrograde path around the moon.
The capsule will be 100 km from the moon's surface at its most distant location.
Three and a half weeks from now, the capsule is going to return to Earth.
One of the key events in the mission takes place that day.
Engineers are worried that the heat shield will not be able to handle the extreme temperatures that will be encountered on re-entry.
32 times the speed of sound will be the speed at which the capsule will come in.
There is a shield on its underside.
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