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Leprosy can reprogram liver cells to grow new tissue, an ability that may help to develop treatments to rejuvenation aging and diseases of the body.
The main symptom of leprosy is disfiguring sores, and it is caused by a slow-growing bacterium called Mycobacterium leprae.
Anura Rambukkana is a researcher at the University of Edinburgh in the UK.
They reported in 2013 that M. leprae hijacks the genes of Schwann cells. The Schwann cells reverting to a stem cell-like state is caused by the reactivation of development genes by the bacteria.
Rambukkana and his colleagues show that Mlep rae can reprogram liver cells as well.
According to Rambukkana, leprosybacteria can grow the organs at an organ level.
The researchers found that infections with the natural host of Leprosybacteria reprogram the entire body into a state of development.
Large numbers of immature liver cells, as well as a large amount of blood vessels and bile ducts, were found in the large animals that were exposed to the disease.
The enlarged livers were perfectly healthy and did not show any signs of disease. Anti-wrinkle genes and those associated with aging were activated by the infection.
There are major safety concerns when it comes to tissue regeneration. The method of turning mature cells into stem cells in the lab can cause aggressive cancer. Our humble leprosybacteria are able to reprogram adult tissues.
It is possible that the secrets of M. leprae could be unlocked.
Luca Urbani is a researcher at the Roger Williams Institute of Hepatology in London. It may help us to understand how to maintain organ structure and function without the development of unwanted effects such as tumours formation and scarring.
The cell reports medicine journal has a reference.
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