Some male cancer cells with X and Y chromosomes show signs of being silenced, according to scientists from the Dana-Farber Cancer Institute.
When a female cell has a pair of Xs, the X chromosomes are silenced.
Randomly turning off an extra X is the body's way of balancing the number of chromosomes. The X and Y don't need to be activated if there is only one X chromosomes.
The rule of thumb is broken in some cancer cells
Cancer patients around the world were used for the findings. Analyzing thousands of genomes representing more than 30 different cancer types, researchers found that the X-in active specific transcript, or XIST, is highly expressed in a wide range of tumors.
The silencing of genes on X chromosomes is a function of the non-coding sequence of the gene.
It is not known if the X chromosomes are silenced in males. It can happen in situations where there are two or more X chromosomes. It can happen in a scattering of cells early in development.
There are 4 percent of male cancers that have a silenced X chromosomes.
It was surprising that a quarter of the rest was associated with non-reproductive cancer.
"We wanted to make sure that this was not just a result of misannotation since XIST is a transcript used to classify female cancers, and so we were very surprised by this result since XIST is a transcript typically used to classify female cancers, and so we wanted to make
Some male cancers of diverse types show features of X inactivation.
They don't know why that is, but they have a few ideas. Multiple copies of the same chromosomes can beMistakes, caused by the rapid proliferation of cancer. There are two X chromosomes in male cancer cells.
It's possible that X inactivation will allow a cancer to survive and thrive.
There are some important genes on the X chromosomes that can be silenced. We will look into this in the future.
The new findings suggest that there is a difference between how cancer cells invade the body and cause destruction.
There was a study published.
All Rights Reserved © 2024
