The first practice was held at the Sao Paolo Grand Prix.
When the track would have had less grip, the Mexican set his time a half hour earlier than Leclerc.
A lap set at the same time as Perez was the reason why Verstappen was third fastest.
Lewis Hamilton and George Russell were in fourth and fifth place, respectively.
Hamilton and Russell were 0.187 and 0.20 seconds off the pace, respectively.
The runners in the middle of the road were from Mick Schumacher'sHaas, Alfa Romeo's Valtteri Bottas, and Alpha Tauri's Pierre Gasly.
The fastest driver not to use the soft rubber in the session was Fernando Alonso.
The session was the last one before the final race of the season.
The starting positions for the grand prix will be determined by the start of the short race on Saturday.
Verstappen complained about a lack of front grip through the session, while Hamilton said his car had a "floaty" feeling.
Sainz will start the grand prix from the back of the grid after his car was fitted with a new internal combustion engine, his sixth of the season.