In a repeat of last season's final, Real Madrid have been drawn in the same section of the competition.
Vinicius Junior scored in the 59th minute to give Real Madrid a win overLiverpool in the final in Paris.
Manchester City and AC Milan play each other, while Spurs play the Italians.
There is German opposition in the club.
French champion Paris St-Germain has been drawn with Germany's top team.
The first and second legs of the last-16 will be held in February and March.
It is the fourth time in six seasons that Real Madrid has been taken on by a six-time winner in the European competition.
In the last two years, Real Madrid has won the title.
In the 2020-21 season, the Spanish champion knocked out the English team.
AC Milan and Real Madrid have won the competition more times than the Reds, who have been in three of the last five finals.
The organisation of the Reds' final defeat in Paris was described as an "abject failure" by European football's governing body.
More than 480 testimonies by supporters and journalists at the 28 May final were examined by an independent panel.
The last-16 draw was full.
Manchester City vs.RB Leipzig.
The club is Club Bruges.
The game is between Real Madrid andLiverpool.
The game is between AC Milan and Spurs.
The game is between Frankfurt and Naples.
The game is between Borussia Dortmund and the Blues.
Inter Milan plays Porto.
The game is between Paris St-Germain and FC Barcelona.
There's more to come.