Egypt is billing the UN's annual climate change summit as a "watershed moment" on climate action.
There are more than 120 world leaders in Sharm el-Sheikh.
Some activists are staying away from the two week summit because of concerns about Egypt's rights record.
Extreme weather is linked to climate change.
The UN's new climate change chief and the Egyptian Foreign Affairs Minister will give welcome speeches at the summit.
The low-lying Caribbean nation of Grenada is at risk from climate change.
The conference will be the world's "watershed moment" on climate action, according to Mr Shoukry.
The UN body for assessing the science related to climate change, the Intergovernmental Panel on Climate Change (IPC), will give a key address.
On Monday, heads of state and government will give five-minute addresses outlining what they want from the meeting.
At the last climate summit, in Glasgow last year, there were powerful speeches from people, like the prime minister of Barbados, who said that two degrees is a death sentence for island countries.
For island nations two degrees is a death sentence.
On Monday and Tuesday, world leaders will speak, and once they leave, conference delegates will begin to negotiate.
A number of pledges were made at the COP26 summit.
The summit should focus on turning last year's pledges into action and getting moving on the massive transformation that must take place.
Money will be the main factor in all of that.
Developing nations are demanding that previous commitments to finance be upheld.
Loss and damage finance is money to help them cope with the losses they are already facing from climate change, rather than just preparing for future impacts. This would be the first time that the issue would be on the formal agenda.
Extreme heat in India and Europe in the summer and devastating flooding in Pakistan in the past year show the seriousness of the issue.
Ahead of the conference, a number of major climate reports were released.
There was no credible pathway to keep the rise in global temperatures below the key threshold of 1.5 degrees above pre-industrial levels.
The 1.5 degree limit was agreed at the 21st UN Climate Summit. This goal has been the focus of all subsequent summits.
There will be hundreds of events over the two weeks with exhibitions, workshops and cultural performances from all over the world.
The protests are likely to be subdued.
The President of Egypt, Abdul Fattah al- Sisi, has been in power for the last three years. As many as 60,000 political prisoners have been held in the country according to rights groups.
The space in Sharm el-Sheikh would be set aside for protests. Many local groups were not able to register for the conference according to Egyptian activists.
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