4:55 PM ET

Gurriel was removed from the World Series roster due to a knee injury.

Gurriel left the game in the seventh after hurting his knee running the bases.

The manager said that he tried everything. He was treated yesterday. Came in this morning and was treated. They didn't respond well enough. He ran. The hardest thing to do for a guy with a knee injury is to stop.

Christian Vazquez will be the designated hitter in the sixth game of the series on Saturday night. The Astros will have more flexibility with their lineup in the final two games.

The designated hitters haven't had much production so far.

In 12 games for Houston, Lee was 4-for-26 at the plate. Gurriel had two home runs and a.347 batting average during the playoffs.

In the best-of-seven series, the Astros are in front.