Son Heung-min's participation in the World Cup is in doubt because he needs surgery to fix a fractured eye.
Son was hurt during Spurs' win in the group stage of the European competition.
"Following surgery, Son will commence rehabilitation with our medical staff and we shall update supporters further in due course," said a Spurs statement.
The first game of the World Cup is between South Korea and Argentina.
When Son will have surgery and how long he will be out for have not been stated by Spurs.
Kevin de Bruyne played for Belgium in the delayed 2020 European Championship 19 days after breaking his nose and eye sockets in the Manchester City final.
Son has scored 35 goals in 104 appearances for his country, who are in the same group as Portugal,Ghana, andUruguay.
The injury is a blow for Spurs and they will have to play on Sunday.
After facing Forest in the third round of the Carabao Cup on November 9th, the side will play their next game in the league on November 12th.
Son has had his form questioned this season but scored a hat-trick after coming on as a substitute in the 6-2 win overLeicester on 17 September and netted twice against Eintracht.