Many of the world's top players will be playing club football until a week before the World Cup starts in November.
Wales boss Rob Page is keeping a close eye on England's squad because of the packed domestic schedule.
Which other countries worry about the fitness of their men?
The BBC tries to keep track of things.
Not many people thought the right-back position would be a problem for him. The situation has changed recently.
The injury to James leaves him a doubt for the tournament.
Kyle Walker was left with six weeks to recover from his groin surgery, but he is confident that he will make the World Cup squad.
KalvinPhillips is a major doubt for the tournament because of a shoulder injury, but he is optimistic that he will be able to play.
Kyle Walker-Peters will be out until the end of the year due to a injury he sustained in Saints' win over Bournemouth.
The winger went off with an injury. "Sak is hopefully not a doubt for the World Cup," said Arteta.
Bale has not played much for Los Angeles FC, but he should be able to lead Wales in the World Cup.
The Rangers forward could be out until December due to a knee injury.
Russel Martin said that Joe Allen has a chance of being fit in time, despite the veteran having not played for more than a month.
The injury list from the defending champion's squad is the largest of any country going into the tournament.
N'Golo Kante will miss the World Cup due to an injury.
He needs more time to recover from knee surgery and won't be playing at the tournament.
The team-mate of Kante is unlikely to play for the Blues before the World Cup due to an injury.
The utility man injured his groin in the win over Barcelona and is expected to make his return in November.
Boubacar Kamara: The 22-year-old tore knee ligaments just eight matches into his Aston Villa career and was expected to be out until after the World Cup but reports suggest his rehab has gone better than anticipated and he could yet make the tournament.
After suffering a leg injury, Raphael Varane left the pitch in tears. The manager said that he will be out until the tournament, but they will have to see how his rehabilitation progresses.
A back injury will keep Anthony Martial out of Manchester United's game against West Ham on Sunday, according to the club's manager.
Richarlison is likely to play for Brazil at the World Cup despite being a major doubt due to injury.
Richarlison was seen on crutches after suffering a calf injury in Spurs' 2-0 win overEverton on 15 October, but his boss says he should be ready for the World Cup.
Richarlison added on Twitter: "Guys, thank God it was just a big scare!! Two weeks and I'll be back! Thank you for the messages and affection."
Arthur Melo: Liverpool's on-loan Juventus midfielder was not so upbeat on social media, saying he expects a thigh injury to keep him out of contention for a place on the plane to Qatar and Reds boss Jurgen Klopp confirmed the injury is "long term" and "really serious".
The manager could be without four important players for the group stage of the tournament.
After being taken off on a stretcher with a thigh injury, Diogo Jota will miss the World Cup.
Pedro Neto will miss the World Cup due to an ankle injury he sustained against West Ham on October 1st.
Porto expect 39-year-old Pepe to be out for several games with a knee injury, while fellow defender Nuno will be out for a few weeks with a muscle issue.
A Die Mannschaft stalwart with 48 caps and 15 international goals is the main worry for the Germans.
Marco Reus had an ankle injury in the fall. He didn't play in the World Cup because of an ankle injury. He came back for the loss to Union Berlin, but has since suffered another blow.
Sane tore his left thigh muscle in the fifth game of the season. He came back to training in November.
Neuer is out with a shoulder injury and the manager doesn't know if he will be able to play in the World Cup. He said that he wouldn't play in it if he continued to have pain.
A potential last-16 opponent for England or Wales will be missing an experienced international operator.
After just playing one game on a loan at Roma, the former Reds player broke his right leg and is out for the rest of the season.
Without a man, the runners-up will have a hard time.
The 28-year-old will miss the competition after picking up a freak thigh injury while taking a penalty.
Angel Di Maria will be out for three weeks with a thigh injury and is in a race against time to be back.
Both the US and England have injuries at either end of the pitch.
It's not known if Dike will return before the November break, as he has been out with a thigh issue.
The Atlanta United centre-back is out for the season with an injury.
There are huge concerns over two of his top stars, but they will be given time to prove their fitness.
The Wolves forward flew back to England on Friday after three weeks in South America recovering from a groin injury, which is a huge doubt for the tournament. The clock is running to be fit.
Sevilla's Jesus Corona broke his leg in August and won't be fit in time to play for Mexico at the World Cup.
Son Heung-min had to be replaced after he suffered a blow to the head.
During Croatia's Nations League win over Austria in September, Inter Milan's Marcelo Brozovic injured his thigh and hasn't played since.
Barcelona stated in September that the defender would likely miss the tournament due to surgery on a torn thigh muscle that would keep him out for 2 to 3 months.
Moder tore his anterior cruciate knee in April and won't be able to play for the Poles.
The captain of Canada, Atiba Hutchinson, has not played all season for his club side, Besiktas, after suffering a bone bruise in pre-season, but hopes to be fit in time for the tournament.
Louza broke his leg against Millwall in October and won't be able to play in the tournament.
All Rights Reserved © 2024
