People with inflammatory bowel disease have a higher rate of colorectal cancer than people without the condition, according to scientists.
In a new study, published in the journal Science, researchers identified a previously unknown class of DNA- damaging molecule, or Genotoxins.
Morganella morganii is a bacterium that is found in the guts of patients with inflammatory diseases and colorectal cancer.
In lab dish experiments, idiosyncrasy damaged genes and caused colorectal tumors in mice.
The scientists were able to prevent tumors in the mice by blocking the production of indolimine.
Cynthia Sears, who was not involved in the study, said that other gut bugs have been linked to cancer.
Some strains of Escherichia coli make a Genotoxin called colibactin which damages DNA and causes tumors in mice.
Our understanding of how otherbacteria may contribute to these diseases has been improved by the new study.
Antibiotics may increase the risk of colon cancer.
Sears said that there is a lot of data that links the microbiome to colon diseases and colon cancer.
The line of research could lead to screening tools that can be used to identify patients at high risk of colon cancer by taking a poop sample.
It could lead to preventative treatments that reduce the amount of cancer-linkedbacteria in patients' guts.
We don't know how to reduce the risk of cancer because we don't know how to stop the clinical associations.
We need to figure out what the mediators are so we can bring something to the patient.
Researchers screened more than 100 types of gutbacteria from the stool samples of 11 IBD patients to find the mysterious DNA- damaging molecule. Inflammation and sores in the lining of the colon and rectum is one of the symptoms of inflammatory bowel disease.
18 strains that damaged the genetic molecule were identified by the team after they were grown in a lab dish with DNA.
The scientists were able to identify the individual molecule that thebacteria produced and which caused the damage.
The researchers found that the DNA damage that they observed did not match the damage caused by colibactin and the flaggedbacteria were unable to make it.
The researchers said that the data implied the existence of previously unrecognized microbiota-derived Genotoxins.
The researchers looked at M. morganii, which has been reported to be present in both IBD and colon cancer patients' guts.
Through this work, they were able to identify the so-called aspartate aminotransferase (aat) gene, which is needed to make indolimine.
The people who live to 100 have unique gutbacteria signatures.
In a mouse model of colorectal cancer, strains of M. morganii caused the tumors to grow more quickly.
The team stopped the growth of cancer by stopping indolimine from being made.
The mouse studies are the best evidence that they have.
The mouse model can't solve all of the problems. Only M. morganii and seven otherbacteria that weren't genotoxic were included in the research.
The scientists were able to observe the cancer driving effects of M. morganii, but didn't capture the complexity of a natural gut microbiome.
There is more work that needs to be done to understand how prevalent M. morganii is.
Sears said that follow-up studies would need to find out how indolimine causes DNA damage and how influential it is over cancer development.
She said that the paper was a first step.
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The original article was published by Live Science. The original article can be found here.
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