According to a source, the tight end is going to be out for two to five weeks with an ankle injury.
The coach said that Njoku's status was week-to-week.
The "Monday Night Football" game will be played before a bye week for the Cleveland Indians.
JacobPhillips is likely to miss the rest of the season with a chest injury. Anthony Walker Jr. suffered a season-ending quadriceps injury in the third week of the season.
Phillips was hurt while making a tackle. He's still being tested.
Denzel Ward is still in the concussion protocol. He was hurt in the fourth quarter against the Los Angeles Clippers and missed two games.
The Cleveland Indians lost to the Baltimore Ravens 23-20 on Sunday. He went to the locker room in the third quarter and didn't come back, leaving the stadium in a walking boot and crutches.
"Be back soon" was posted by Njoku later in the day.
Before he left the Baltimore game, Njoku had seven catches on seven targets for 71 yards. He leads the team with 34 catches for 418 yards and a touchdown.
The AP contributed.