Yokohama National University is located there.
A group of researchers from Japan have successfully grown hair in cultures. Useful applications in treating hair loss disorders, animal testing, and drug screenings could be contributed to by the understanding of hair follicle development.
Their findings were published in a scientific journal.
The epidermal layer and mesenchyme are involved in the development of an embryo. The interactions are similar to a messenger system that causes hair follicle growth. In an organisms, cells are organized into tissues and organs.
Scientists have used animal models to explore important mechanisms related to hair development. Hair follicle morphogenesis has not been reproduced in a culture dish because of the challenges of fully understanding these mechanisms.
Organoid cultures have been receiving a lot of attention. Scientists use organoids to study tissue and organ development in a laboratory culture dish. An assistant professor with the faculty of engineering at Yokohama National University said that organoids were a promising tool to understand the mechanisms in hair follicle Morphogenesis.
The research team used a low concentration of matrices to control the structure of hair follicle organoids. The framework of the body is called the extracellular matrix. The spacing between the two types of cells was adjusted by the matrix. The core-shell-shape groups contained newly formed hair follicles. The groups increase the contact area between the cell regions.
The research team used the organoid culture system to grow hair. The hair follicle organoids produced hair with long hair shafts. The researchers were able to understand the signaling pathways involved in the process of hair growth as a result of this growth.
They looked at the feasibility of hair follicle organoids for drug screening. A melanocyte-stimulating drug was added to the culture medium. The researchers were able to improve the hair color with the addition of this drug. They were able to achieve efficient hair regeneration with repeated hair cycles by using the hair follicle organoids. For better understanding of hair follicle induction, for evaluating hair pigmentation and hair growth drugs, and for regenerating hair follicles, the in vitro hair follicle model could be useful.
The findings of the researchers could be relevant to other organ systems. The team wants to improve their culture system with human cells. Junji Fukuda is a professor with the faculty of engineering at Yokohama National University.
Their research could eventually lead to the development of new treatment strategies for hair loss disorders that are common in both men and women.
More information: Tatsuto Kageyama et al, Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction, Science Advances (2022). DOI: 10.1126/sciadv.add4603. www.science.org/doi/10.1126/sciadv.add4603 Journal information: Science Advances Provided by Yokohama National University
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