He was not expecting to see a zombie when he set off into the jungle. The Tambopata National Reserve is located in the southeast corner of the country and is famous for its diversity of flora and fauna. He wanted to document some of its rarer residents, such as jaguars, so he set off along the narrow trails.

He found an unparalleled situation for lovers of thehidden universe. The remains of a fly were on top of a leaf. A half-dozen stalks-like formations sprouted from its body. They were in a way.

There is a group of real-world body snatchers called the Ophiocordyceps. The flies, ants, and other insects are forced to move to higher areas due to the control of the fungi on their movements. Spore bombs are fruiting bodies that erupt through the host's body and are released by the parasites. As many insects as possible are infecting these spores.

Wait until you hear about the wasp that takes over the mind of a roaches and then ride it all the way home as a packed lunch.

While some members of the parasitic fungus genus <em>Ophiocordyceps</em> seek out insect hosts, this species, <em>O. caloceroides</em>, takes up residence in spiders, such as this tarantula photographed in Ecuador.
While some members of the parasitic fungus genus Ophiocordyceps seek out insect hosts, this species, O. caloceroides, takes up residence in spiders, such as this tarantula photographed in Ecuador. Ian Suzuki, CC BY 3.0/Wikimedia

Half of all animal species are parasites. A lot of these plus-ones take complete control of the organisms they have invaded by manipulating their host's behavior. Scientists are able to understand how body snatchers take over their victims thanks to advances in technology. Humans are at risk from a few of them Most parasites haven't had time to figure out how to turn us into compliant hosts because we're young. It's still yet.

Racz, collections manager of the Manter Laboratory of Parasitology at the University of Nebraska-Lincoln, said that insects have been around for millions of years. Humans are a couple hundred thousand years old, and we are complex.

Racz watched the movie The Host a couple of years ago and it showed aliens controlling people. It's a good movie, but I was watching it as a scientist and it's impossible to control insects.

While parasites aren't great at grabbing the reins of complex organisms, the ones that can manipulate the behavior of their hosts are very, very good at it.

Racz says that the parasites target a simple hormonal system. It is more about triggering some existing behavior.

“The arms race doesn’t exist. It’s static and the parasite is winning.”

Take that insect. The female jewel wasp (Ampulex compressa) attacks an American cockroach with a single punch or sting that targets precise areas of its nervous system. The roach is partially immobile. The wasp can climb up on the roach's back, grab its antennae and lead it back to her nest with the second cocktail of venom. Eggs are laid in the roach and leaves. The wasp's offspring kill the roach.

The senior author of the Journal of Experimental Biology paper, Frederic Libersat, is a neuroscience professor at Ben-Gurion University of the Negev in Israel. Libersat believes that host-manipulating parasites are genius because they can't evolve out of the situation.

A mollusk-eating crab will eventually develop larger, more powerful claws as it continues to evolve an ever-thicker shell. He says that the arms race doesn't exist. The parasites are winning.

Host-manipulating parasites can hijack existing systems by flooding them with chemicals it already needs to function. The hormone dopamine and the neurotransmitter GABA help to regulate movement in organisms from hapless roaches to humans. The jewel wasp has two chemicals in its venom that allow her to control the roach.

The female jewel wasp <em>Ampulex compressa</em> stings her cockroach target twice, first immobilizing it and then flooding it with dopamine and other chemicals that allow her to control its movements.
The female jewel wasp Ampulex compressa stings her cockroach target twice, first immobilizing it and then flooding it with dopamine and other chemicals that allow her to control its movements. Len Worthington, CC BY-SA 2.0/Wikimedia

The animal has no way not to use something that the parasites have access to. Dopamine is so important to an organisms basic functions that it can't simply evolve out of needing them. Libersat says that the way he will fight in the arms race is to remove all the dopamine in his central nervous system. It won't do anything.

Libersat and his colleagues in the emerging field of neuroparasitology have been able to explain what is happening on a molecular level. Libersat says that most of the studies before were descriptive. They showed some manipulation and said it was very interesting. We didn't pin down the mechanism.

Thanks to the ability to turn specific chemicalreceptors on and off in organisms, researchers are able to see exactly what is happening in both host and parasites.

It's not known much about the host-manipulating skills of parasites. Libersat and his peers have made a lot of progress in understanding how parasites control a host, but the mechanism behind more complex behavior manipulation is still not known. The Japanese oakblue butterfly's caterpillar has a sweet substance that ants like to eat. The treat has chemicals that make the ants stay close to the caterpillar and also act aggressively towards its potential prey. Immediate bodyguards. The cocktail that the caterpillar serves appears to affect the ants' dopamine levels, which may make them less likely to wander away.

Japanese oakblue butterflies (<em>Narathura japonica</em>, also known as <em>Arhopala japonica</em>) get a leg up on survival as caterpillars by recruiting and controlling a phalanx of ant bodyguards.
Japanese oakblue butterflies (Narathura japonica, also known as Arhopala japonica) get a leg up on survival as caterpillars by recruiting and controlling a phalanx of ant bodyguards. Alpsdake, CC BY-SA 4.0/Wikimedia

The mechanism that causes what scientists call "suicidal behavior" is largely unknown. The behavior is connected to the parasites moving from one place to another. The intermediate host has to be sacrificed when they jump them. Most of the odd behaviors occur when the host is in the intermediate host.

The lancet river fluke has a life cycle that involves multiple hosts and an ant. The ants eat the slimy mucus-coated lump produced by the snails. The same part of the insect's brain that was targeted by a jewel wasp after it was eaten is also the same part of the insect's brain after ingestion. A normal ant wouldn't do something like that when it's brain is infectious. The blade of grass or flower is at just the right height to be eaten by the last host.

Racz says that a sheep or cow can accidentally ingest an ant that has been bitten by a flatworm.

In a paper published in Scientific Reports, the authors were able to document the presence of the fluke in the ant's brain, but were not able to determine how it forced the ant to offer itself up to cows.

Body-snatching parasites don't need to get into the host's brain. The fly that was attacked by Ophiocordyceps was able to build its own communication network in its muscles. Gibellula is one of the genera of parasites that do something similar to spiders. In a paper published in the Canadian Journal of Zoology, it was stated that Gibellula-infecting spiders, like Ophiocordyceps-infecting insects, climb to a higher position than uninfecting ones. The spider's body is eaten by the parasites and they send up fruiting bodies. There is a corpse that is fuzzy and spider-shaped.

Fruiting bodies of a member of the parasitic <em>Gibellula</em> genus poke out from the exoskeleton of a spider that the fungus devoured from the inside out.
Fruiting bodies of a member of the parasitic Gibellula genus poke out from the exoskeleton of a spider that the fungus devoured from the inside out. Katja Schulz, CC BY 2.0/Wikimedia

The greatest threats to our species are less dramatic than they are frightening. One billion people have been affected by the single-cell parasites Toxoplasma gondii, according to a 2020 paper. Babies and people with weak immune systems can be killed by infections. When the parasites settle in the brain, they can cause psychotic symptoms.

The wily parasites can find a home in almost any part of a warmblooded organisms, but it is when it is nestled in the brain that it is able to manipulate behavior to its advantage. There are many examples in which animals with toxoplasmosis become less afraid of their natural prey and are more reckless, leading to increased risk of being eaten. Chimpanzees showed less fear of the scent of urine from their only natural predator, the cheetah, than healthy Chimpanzees. It has been shown that toxoplasmosis can raise testosterone levels in animals, which could account for the loss of fear and aggressiveness seen in many species. Humans are just one of many animals that have been damaged by the parasites.

The cat is the last host of T. gondii. The parasites need to find their way into a cat. The ease with which humans can get infections through food, water, or air has led some researchers to suggest that our relationship with the parasites is one of the oldest in our family tree.

Humans have been haunted by Lyssaviruses for as long as any of us has been alive. The members of this group cause inflammation of the brain that leads to thirst, aggression, and other symptoms that are all in service to the goal of spreading the disease to other animals. You know the disease it can cause, even if you don't know the name of the group.

Foxes are particularly problematic natural hosts for lyssaviruses, which can cause rabies. They often travel thousands of miles, potentially spreading the virus far and wide.
Foxes are particularly problematic natural hosts for lyssaviruses, which can cause rabies. They often travel thousands of miles, potentially spreading the virus far and wide. Elaine R. Wilson - naturespicsonline, CC BY-SA 3.0/Wikimedia

Racz says that the rabies virus is an interesting one because it attacks nerve cells, and once it gets into the nerve cells, it is irreversible.

The natural hosts of most lyssaviruses are mammals. The animal becomes aggressive, loses its fear, and salivates with excessive thirst once it's been bitten. They are alive and well and are not dead. Racz says they're restless and move a lot. Changes in an animal's behavior increase the chance of a successful spread of the disease.

Racz says that mind controlling parasites are not common in mammals. He says that they don't have a lot of examples.

Host-manipulating parasites can be frightening, but they can also be important for understanding why our brains and bodies behave the way they do. Scientists have only been studying the ins and outs of their intended hosts for a long time.

Libersat says that it gives us a window on how behavior is generated in simple animals.

He says that the parasites are nature's neurobiologists. Neuroscience tries to find the neural mechanism of a given behavior; they investigate the circuits that are involved in producing the behavior and then manipulate them with drugs.