The last time a British club lifted the title was 16 years ago. Is this the season when the run is over?
After Manchester City, Glasgow, and Glentoran failed to make it through qualification, the group stages will begin this week with two teams flying the flag.
The Women's Super League sides will need to get off to a good start.
Lyon, last year's semi-finalists, will be the visiting team, as will last year's quarter-finalists Paris-StGermain.
Can they win the title this time? Let's see who is involved and what to watch for.
If the two teams are to make it to the finals of the European club competition this year, they will have to do it the hard way.
The winner of the Women's Super League will automatically qualify for the group stages, while the loser will have to go through a qualification round.
After failing to make it out of their group last season, it will be difficult for them to make it to the knockout phase this time around.
In the past two seasons, Real Madrid and Manchester City have been knocked out of the playoffs by Lyon and Lyon, respectively.
The Blues will be without their manager as she recuperates from emergency surgery.
The unenviable task of facing eight-time winners Lyon in Group C, as well as Serie A winners Juventus - quarter-finalists last time out - is something that will be difficult for the defending champion.
If the two London clubs can put on strong showings in their groups, they may fancy their chances of making it to the next round.
It's not easy to overlook Lyon, who beat Barcelona in a thrilling game in May.
The competition's record scorer, Ada Hegerberg, came back from injury to play a crucial role in the French side's run to the title last season and she will look to bounce back from her Euros disappointment with Norway.
Many English fans will want to see their Lionesses win the European Championship, and two of them - former Manchester City players Lucy Bronze and Keira Walsh - have given themselves a great chance of silverware by joining Barcelona.
Ballon d'Or winner Alexia Putellas is likely to miss the rest of the season as she recovers from knee surgery, but the Spanish champion are still in the running.
Bronze and Walsh will face off against their England team-mate Georgia Stanway in the group stage. They beat Lyon at home in the group stages and then went to extra-time against Paris Saint-Germain in the quarter-finals.
The easiest route to the knockout stages for two-time winners Wolfsburg is through the German league. They are in a group with four other teams.
Popp scored six goals for Germany in the tournament and only missed out on the Golden Boot to England, but she did get an assist.
In their six group wins, Paris Saint-Germain scored 25 goals without reply. Their ranks have been boosted by the signing of Lieke Martens from Barcelona, but Marie-Antoinette Katoto remains out with a serious knee injury.
There are some fresh teams in this year's group stage of the European competition.
The teams that weren't in the group stage last year are present.
KF Tirana became the first club from Albania to reach the last 16 of the men's European Cup in 1989.
For the first time ever, the runners-up of the Serie A have made it to the group stage as they try to get into Europe's top club competition.
The first Czech team to make it to the group stage is Slavia Prague, who missed out on the playoffs last season.
Under the old competition format, St Polten made it to the last 16 two seasons ago.
It is hoped that the record crowds seen at the Euros can be repeated at the larger grounds used for the men's team.
The crowd of 47,300 at the recent north London derby against Spurs was a record for a WSL game.
Barcelona will play their home group-stage matches at the 99,354-capacity stadium after drawing in more than 90,000 spectators for their quarter-finals against Real Madrid and semi-finals against Wolfsburg.
All Rights Reserved © 2024
