Shields beat Marshall in a unanimous decision in London to become the undisputed champ.
In a career-best performance, the American avenged her only defeat on her pro and amateur record and staked her claim as one of the best fighters in the world.
On a historic night for women's boxing, all three judges saw it in Shields' favor as she claimed six titles.
After a night of firsts at the O2 Arena, both women talked about a possible second fight.
It was the first time two female boxers had fought at a major venue in the UK.
The fight was full of action and edge-of-your-seat exchanges as Marshall showed incredible heart and determination to stay a constant threat.
If fans get to see a second and even third fight, it could turn into one of the greatest rivalries in boxing history.
It was also a fight of the year contender, the perfect follow-up to the amazing fight that took place at Madison Square Garden in April.
In the course of six months, the female code has produced two undisputed fights, a sell-out at a major venue and two fight of the year hopefuls.
In her post-fight speech, Shields was emotional but happy as she insisted that the night belonged to her.
It's not just a special moment for me, it's a special moment for women's boxing as well.
Women's boxing has been around for a long time and many greats have come before us, but here we are in front of 20,000 fans at the O2 Arena and I think that's the best fight of the year.
It's an unbelievable moment, I'm just so happy.
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