A source told Jeremy Fowler on Tuesday that the ankle injury suffered by Baker Mayfield will take two to six weeks to heal.
The source said that it would be difficult for him to play on the injury.
PJ Walker is expected to start for the Los Angeles Rams against the defending Super Bowl champion. The firing of Matt Rhule came after he lost 11 games in a row.
The injury happened late in the first half of the game. The first pick in the draft, who wore a walking boot on his left foot, arrived for his postgame news conference.
This year's slow start is due to the subpar play of the player. He had a pick-six at the end of the first half against the Rams and his Total QBR is the second lowest after five games of any quarterback.
The only healthy quarterback on the active roster is Walker. Sam Darnold was placed on injured reserve after he injured his ankle in August.
DavidNewton was a contributor to this report.