LIVE on Sky Sports, Trent Alexander-Arnold andJoel Matip are out for two weeks.
After sustaining a knee injury in Sunday's game, Luis Diaz is expected to be out for the rest of the year.
No surgery will be required for the 25-year-old after he underwent a Scan after the match.
While holding a game in hand, the Reds will be without three players as they face City at home on Sunday.
The first goal of the game was scored by Darwin Nunez, who was assisted byDiaz.
He lasted just 42 minutes before being replaced by Roberto Firmino, who scored the second goal of the game.
Alexander-Arnold was taken off with an ankle injury after he was caught by Gabriel Martinelli while Matip had a calf injury.
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Two years ago, when they had just ended their 30-year wait for the title, their form collapsed after suffering a run of defensive injuries that affected other areas of the team.
In the 2020-21 campaign, the side looked a shadow of themselves as they were unable to implement their gegenpressing ideas and had to use makeshift centre backs instead.
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This season has seen a similar run of injuries affecting all areas of the team, meaning that Klopp has been unable to use the new five substitute rule as much as he wanted.
This has then led to more players in the physio room, with Alexander-Arnold and Luis Diaz both forced off with serious injuries, while Arthur Melo is currently out for three months after tearing his quad.
With so few options to take their place in the team, Alexander-Arnold has not always been given a rest away from the public gaze. Due to a lack of fit replacements he has had to call on 36-year-old James Milner.
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