The New York Giants ruined the party for the Green Bay Packers as they fought back to claim a 27-22 victory.
The Green Bay Packers were playing their first regular season game outside of the US and they were the last team to play in London.
Rodgers was the first reigning Most Valuable Player to play in London in four years.
Rodgers threw two touchdown passes in the first half as the Packers took a 20-10 halftime lead.
New York quarterback Daniel Jones and running back Saquon Barkley stole the show from Rodgers.
The Giants didn't have to give third-string quarterback Davis Webb his first career start because Jones shrugged off an ankle injury, and the fourth-year quarterback led the Big Blue to a big upset.
After Gary Brightwell's touchdown at the start of the fourth quarter, the Giants tied the game and then took the lead on a touchdown by Saquon Barkley with six minutes left.
The Giants have reached the play-offs just once since winning their fourth Super Bowl in 2012 but they held on to improve their record to 4-1 while the Packers are now 3-2.
It took the Packers so long to play in London because they were unwilling to give up a home game because of the huge demand for tickets back in Green Bay.
It felt like the Packers were at Lambeau Field, with their Europe based fans coming out in force as they finally got to see their idols in the flesh.
Green Bay's cheeseheads outnumbered the Giants fans in the stands at the London Olympics.
After watching Rodgers make his first pass down the middle to Randall Cobb, they created a loud atmosphere in north London.
A pass interference penalty against New York on a deep play by Rodgers allowed the Packers to march to the Giants' four-yard line and open the scoring.
The Giants got on the board with a field goal at the end of the first quarter, but the Packers went on to score 17 unanswered points.
Green Bay's second touchdown was scored after Rodgers floated the ball to a wide-open Lewis in the end zone.
The Giants capped their 86-yard drive with a well-executed play, which saw a double hand-off and a switch in direction, after Daniel Bellinger spotted a gap to dive into the end zone.
New York's Graham Gano kicked his second field goal in the third quarter, which saw the Giants briefly lose a player.
Gary Brightwell ran over from two yards after Jones engineered a 91-yard drive that lasted over eight minutes.
After coming back into the game, he caught a 41-yard pass and ran for two yards to finish the drive.
With just over a minute left, Green Bay were on New York's six-yard line and Rodgers was able to plan a game-tying drive.
The Giants were able to get the ball back and run the clock down by forcing a safety.
There would be no heroics from Rodgers as he was sacked as he tried to escape a desperation attempt.