The San Siro was the scene of AC Milan's easy win over the Italians.
This was a perfect riposte as England centre-back Fikayo Tomori smashed in the opening goal.
Brahim Diaz, a former Manchester City player, scored twice in the second half to put the game out of reach.
The result moved Milan third in the league, level with leaders Napoli.
Since joining Milan, Tomori had only scored one goal in Italy, but he showed great composure to blast past Szczesny at the half-time break.
He was responsible for blocking the goal-bound strike. He drove the ball high into the net.
Diaz latched on to a loose pass from Dusan Vlahovich and fired in off the palms of Szczesny.
In injury time, Origi had a chance to make it three but Szczesny was equal to the task.
Massimiliano Allegri'sJuventus have struggled this season and are yet to win on their travels, but had at least started well, only to be overwhelmed by a rejuvenated Milan.
The side that crumpled in London was very different, and Tuesday's match is shaping up to be a good one.
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