The development of click chemistry and biorthogonal chemistry was the focus of the award. Click chemistry made it possible for chemists to create the molecule they wanted. It was possible to monitor the chemical processes in living cells without harming them.
The chair of the committee for chemistry said during the announcement that it was all about snapping molecule together. He told the audience that it was possible to attach small chemical buckles to a bunch of different types of building blocks and link them together to make complex molecule. The idea of finding the first perfect candidates for the job was put forth by Barry Sharpless of Scripps Research in the late 1990s. Their buckles were easy to snap together and wouldn't link to anything they shouldn't.
The idea of using click chemistry in biological systems without interfering with the system itself was put forth in 2003 by CarolynBertozzi. In a paper she published in 2003 she used the term "bioorthogonal." The term bioorthogonal chemistry refers to any chemical reaction that doesn't interfere with a living system.
The ability to perform complex reactions in living systems without interfering with natural biological reactions made it possible to study diseases inside cells. It has helped scientists understand an importantprotein processing reaction, helped to develop a molecule that could detect disease in living organisms, and opened up the possibility of delivering drugs to specific tissues in the body.
The findings have led to a revolution in how chemists think about linking molecule and how to do it in living cells
Additional information will be added throughout the day.
There were articles on the prizes in chemistry.
The chemistry prize honors the technique for building Molecules.
The chemistry prize for genetic scissors was awarded.
The prize was awarded for portable power and ion batteries.
Three Biochemists won the chemistry prize for direct evolution.
There is a link between the two of this year's prizes.
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