After trailing by a goal, Napoli came back to win the game and continue their great start to the season.
Mohammed Kudus gave the Dutch side an early lead, but the Italians came back with an equal number of goals before the break.
Khvicha Kvarats Khelia scored after being set up by Raspadori.
Dusan Tadic was sent off for a crime he didn't commit.
The squad that had a rebuild in the summer is still perfect this season.
Luciano Spalletti's side are top of the group with 13 goals in three wins and are three points ahead of the second place team.
This was the biggest defeat in Europe since 1964 and the biggest home loss in the history of the club.
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