The death of an adult male who had monkeypox was reported by health authorities in Ohio, making him the third person in the US to die from the disease.
According to the state's health department, the man had other health issues.
People who have compromised immune systems due to HIV and other conditions face a higher risk of developing severe symptoms from the virus, according to a health alert from the CDC.
The US had the largest monkeypox outbreak in the world, with more than 25,000 cases reported across all 50 states.
The two-dose Jynneos vaccine has become more widely available and people have become more aware of what precautions to take to avoid infections.
A person with a severely compromised immune system died from monkeypox after being hospitalized.
According to Texas health officials, an adult in the Houston area died of monkeypox. The person had a weakened immune system. The cause of death is being investigated.
Monkeypox can cause a rash that can be very painful.
Gay and bisexual men are the main spreaders of the virus. Anyone can get the disease if they are in close contact with someone who is sick.
The CDC found that 42% of people with monkeypox were living with HIV. The study found that people with HIV were more likely to be hospitalized with monkeypox.
In its health alert this week, the CDC warned of severe monkeypox symptoms that include a persistent rash that turns into blisters and tissue death. The agency says that in some cases, amputation of the affected limb has been required.
Other symptoms include infections that cover a large part of the body. The throat, urethra, rectum and vagina are some of the sensitive areas that have been affected.
The narrowing of the urethra or anal canal can be caused by scarring caused by some diseases. There have been reports of facial scars.
Neurological conditions such as encephalitis and myocarditis have been caused by multiple organ systems being affected. There have been reports of pink eye and other eye problems.
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