Tom Brady came up just short of a comeback as his team lost to the Packers.
The two defences dominated in what could be the final meeting between Brady and Rodgers.
In the heat of Florida, the Miami Dolphins defeated the Buffalo Bills to improve to 2-0 on the season.
The Chicago Bears won with the last kick of the game to move to 2-0, the Philadelphia Eagles moved to 2-0, and the Las Vegas Raiders fell to 0-3.
In what could be the last meeting of two of the greatest quarterbacks of all time, Rodgers had a hot start and threw two touchdown as the Packers bottled up Brady, who with two minutes left in the game had more Super Bowl wins than points on the board.
Brady has managed more fourth-quarter comebacks since the merger of the NFL and he led an 89-yard drive that ended with him hitting Russell Gage Jr for a touchdown with 14 seconds remaining.
A two-point conversion was needed to force overtime, but Brady was unable to find his man and Rodgers was able to celebrate his second win over Brady.
Over the years, it's been a lot of fun competing against Tom, and it's always nice to come out on top.
He has been a pioneer in our position for a long time.
The Buffalo Bills were beaten by the Miami Dolphins 21-19 in the heat of south Florida.
Josh Allen threw for 400 yards as the league's top scorer dominated the ball, having twice as much possession and running 90 plays to Miami's 39, but Miami proved it's what you do with the ball that counts.
QB Tua Tagovailoa returned after leaving the game with a suspected concussion to lead Miami into a fourth-quarter lead, and Buffalo simply had nothing left as several players left the game with heat illness.
While the Bills have big injury issues to deal with and a wider worry that they've now lost the last seven close games they, the Dolphins, despite giving away two points when their punt went against their man in the end zone, hung on to improve to 2-0.
A Bills assistant coach became a social media sensation when he trashed his notes and computer after the game.
Every week there is a shock or two, and this week was no different as the Colts shocked the previously perfect Kansas City Chiefs.
The Colts capitalized on a number of errors by the Chiefs as veteran quarterback Matt Ryan threw the winning touchdown pass with just 24 seconds left in the game.
There are signs that the rebuilding process is heading in the right direction, as evidenced by the fact that the Jacksonville Jaguars beat the well-fancied Chargers 38-10 in Los Angeles.
The way the Jacksonville defence handled injured quarterback Justin Herbert will be the biggest plus for the team.
The Philadelphia Eagles dominated the Washington Commanders in a game where they sacked and hit their former quarterback.
New Eagles quarterback Jalen Hurts is the toast of Philadelphia as he threw three more touchdown passes, while receiver DeVonta Smith produced a one-man highlight reel showing as Philadelphia look to have their best squad since their Super Bowl success five years ago.
The Atlanta Falcons surprised a lot of people with their victory in Seattle, as they were the first team to win a game this year.
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