After playing onetime roles throughout 1959 and the early 60s on shows such as The Untouchables and Maverick, Fletcher went on to become an actress. She was 5'10 and producers thought no one would see her as attractive.

She would play Nurse Ratched in Milo Forman's adaptation of Ken Kesey's novel. She won a Golden Globe, a BAFTA, and an Academy Award for her performance in that role. She had a good career in both film and TV, with roles in films such as Invaders from Mars and Virtuosity. She appeared in a number of shows on TV.

Star Trek: Deep Space Nine was the longest TV role of his career. In the first season finale of the show, she played a Bajoran cleric named Kai Winn who was able to draw the students of the Deep Space Nine school to her side. She would become a recurring antagonist throughout the series, often making power plays to advance her own career. James said that Winn was one of the best villains in the series. He said that Fletcher was one of the biggest assholes in the show. It was a great performance on a piece of work character.

As Rosie on Girlboss, he was a recurring actor on the show. The last series would be her last.

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