A group of scientists warned in a review of research that the global outbreak of monkeypox could lead to a number of neurological issues, including nerve pain, seizures, brain inflammation and mood disorders.

People check in to get a monkeypox vaccination at a new walk-up monkeypox vaccination site

The people are waiting to get a vaccine.

Los Angeles Times via Getty Images

In a peer reviewed paper, researchers said that nerve pain, seizures, encephalitis, brain inflammation, and anxiety and depression are all related to infections with Viruses that are closely related to Monkeypox.

While few major neurological issues have been reported during the global monkeypox outbreak, the researchers warned that similar "complications are to be expected" in monkeys.

Those with compromised immune systems, such as some people living with HIV or AIDS, are particularly at risk as the monkeypox virus may be able to persist in the body for longer or more.

The researchers said that clinicians should be on the lookout for neurological side effects from the vaccine given to a large number of people.

Older vaccines used against smallpox, which could also be used against monkeypox, use a related virus called vaccinia, which can cause serious side effects.

The researchers said clinicians should remain vigilant of any adverse reactions to the Jynneos vaccine being used in monkeypox campaigns, even though newer and safer than previous vaccines.

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Though scientists have known about the disease for a long time, it has largely been ignored by the world. The virus does not transmit easily between people, but experts fear it could one day spread and fill the void left after the eradication of the disease. The cases were not linked to travel in the affected regions. The scope, scale, geographic range, speed and demography of the outbreak set it apart from previous flare ups, which have usually been relatively confined and burned themselves out. The data from the outbreak shows that the virus is almost exclusively spreading through sex between men and that it has a different set of symptoms than in the past.

Big Number

A total of 62,408. According to the CDC, there have been confirmed cases of monkeypox in the world so far this year. More than a third of these have been recorded in the US. There have been a decrease in monkeypox cases in the US and Europe in recent weeks, though it's not clear if it's due to vaccinations or changes in behavior.

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