Lance left the game in the first quarter with an ankle injury and will not return.
Lance stayed on the field for a while after taking a hit from Barton. His teammates quickly gathered around him to give him encouragement after he left the field on a cart and headed to the locker room.
Lance had the option to pass the ball to Ray-Ray McCloud or keep it. Barton met him in the hole after he kept it and ran up the middle. Lance's right leg appeared to fall under him.
Jimmy Garoppolo entered the game and completed his first attempt for 4 yards before the Niners settled for a field goal.
Lance had three runs for 13 yards before he left.
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