In their Women's Super League opener, Maya Le Tissier scored twice on her debut for Manchester United.
Le Tissier was a centre-back and scored two goals from corners.
The captain of the United made her 100th appearance and scored one of her own.
There was a record crowd at the Leigh Sports Village for the first half of the game.
It was a great start for the side, who are trying to get into Europe.
Skinner gave a debut to a Spain forward in the starting line-up, as well as a place on the bench for two other players.
Reading struggled to cope with set-pieces and the creativity of the United attackers.
Zelem calmly put away the penalty that she was brought down for, as she looked sharp in the first half.
Goals from Le Tissier - a looping volley and a thumping head - came either side of Zelem's spot- kick and all but confirmed victory with less than half an hour played.
Although Lauren Wade came close in the first half, they rarely tested United goalkeeper Mary Earps.
The next match for Kelly Chambers' side will be on the road as they take on the Seagulls, who lost their first match to the Gunners.
Canada forward Leon was one of the new signings named in the United's team.
Many people were excited to see Le Tissier. The England youth international was wanted by the Blues in the transfer market after impressing atBrighton.
She was signed by United to strengthen their backline, but she also offered an attacking threat.
Zelem's set-pieces were once again excellent and Le Tissier will fancy her chances of adding to her tally with that service.
Zelem had a great game for United in his 100th game, but the fans were treated to a goal from Russo, who played for France at the European Championships.
Fans queueing outside the stadium's entrance for at least two hours before the game to welcome the players, with England's Toone receiving a warm reception.
Both Toone and Russo missed chances to extend United's lead, but their contribution this season will undoubtedly play a key role in the quest for Europe's top club competition.
There wasn't much for Reading fans to cheer about, although Scotland defender Emma Mukandi captained the side for the first time.
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