There is a Max-Planck-Institut fr Biologie Tbingen.
The human gut is made up of many different types ofbacteria and archaea. The Max Planck Institute for Biology in Tbingen has discovered gut microbes that share a similar evolutionary history with their humans. Some microbes have features that make them dependent on their hosts. The results of a study done with data from 1,225 individuals out of Africa, Asia and Europe have been published in Science.
There are many different types of microbe in the human gut. The strains of the microbe are vastly different between people. Little is known about the origins of these strains. Most of these strains are found in the human gut. The question of where the organisms come from is raised.
The histories of people and things.
As humanity diversified and spread over the globe, the research team speculated that certain species and strains have been with people. The evolutionary histories of humans and of gut microbes were compared for the first time by researchers from the University of Tbingen.
The researchers used statistical tests to find out how well the trees they created match the ones in the human study. More than 60% of the investigated species matched with the evolutionary history of their human host, which means that these microbes co-diversified over 100,000 years in the human gut. Ruth Ley is the head of the department for Microbiome Science at the Max Planck Institute for Biology, Tbingen, where the study was conducted.
GutMicrobes became dependent on their hosts.
The strains that followed our history most closely are now those who rely on the gut environment. The human gut environment has made it difficult for some of the microbe strains to survive outside the human body. The weaker association with the human history showed more similarities to free livingbacteria.
Taichi Suzuki and Liam Fitzstevens are the main authors of the study. The microbes are dependent on the human body environment. We have seen that some human gutbacteria are more dependent on their host than we thought.
Ley says that this changes how we view the human gut.
A population-specific approach to therapies.
The research team analyzed the gut microbes and genomes of 1,225 people in Europe, Asia, and Africa. Researchers from the Institute for Tropical Medicine at the University of Tbingen helped collect the stool and saliva samples. Researchers around the globe supported the study by providing similar data from participants recruited in other countries.
The local human population has long been associated with certain types of microbes. Microbiome-based therapies of diseases can be refined and adapted to a specific population.
More information: Taichi A. Suzuki et al, Codiversification of gut microbiota with humans, Science (2022). DOI: 10.1126/science.abm7759 Journal information: Science Provided by Max-Planck-Institut für Biologie Tübingen
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