Tom Brady's team won their first game of the season with a dominating defensive performance against the Cowboys.
Brady became the first 45 year old starting quarterback in the history of the league when he threw a touchdown in the victory.
The Green Bay Packers lost to the Kansas City Chiefs, but the reigning most valuable player lost to them.
After coming out of a short-lived retirement that lasted just 40 days, Brady looked good despite missing 11 days of pre-season because of personal issues.
As he begins his attempt for an eighth Super Bowl, Brady didn't have to do too much for the new head coach of the Buccaneers who has Leonard Fournette running for 127 yards.
Dallas were held to their lowest opening game score for 33 years, and will now be without starting quarterback Dak Prescott as he needs surgery on a fractured thumb picked up late in the game.
The Kansas City Chiefs won their first game of the season for the eighth year in a row, while the Green Bay Packers lost their opener for the second year in a row.
Only three players in history have thrown five touchdown passes in a game for the sixth time in their career, and Patrick Mahomes did it for the sixth time.
Rodgers didn't throw a touchdown pass for the second year in a row as the Packers lost to the Vikings.
With Davante Adams moving to the Las Vegas Raiders, the Packers will face a tougher challenge this year than they have in the past.
Adams had 141 yards and scored his first touchdown for the Raiders, but it wasn't enough as they lost to the Los Angeles Clippers.
The third-year quarterback threw three touchdown passes for the Bolts, who are expected to challenge with a much improved defence this year.
The New York Giants started the season with a 21-20 victory over the TennesseeTitans, thanks to a missed field goal by the kicker.
The New EnglandPatriots have not recovered from losing Brady in 2020 and could be in for another tough season judging by their 20-7 defeat at the Miami Dolphins.
Only two head coaches in NFL history have won more games than New England's Bill Belichick, but he still has a big rebuilding job on his hands as he lost to Miami's rookies.
In his first game since the Super Bowl, Cincinnati's quarterback was sacked seven times and turned the ball over five times in a 23-20 loss to Pittsburgh.
After throwing a touchdown pass to Ja'Marr Chase with two seconds left in the game, the kicker missed the extra point that would have won the game for the Bengal.
Boswell secured the victory with the last kick of the game from 53 yards, after both McPherson and Boswell missed chances to win it. Both Super Bowl teams lost in their season opener for the first time in 17 years, as the Los Angeles Rams and Cincinnati Reds lost on Thursday.
It was the first time in 43 years that the Indianapolis Colts and Houston Texans were tied in the same week.
The Colts came from 17 points down in the fourth quarter to force overtime but their kicker missed an opportunity to win the game.
One kicker who did hit a game-winner was Cleveland's Cade York, who made a 58-yarder in the fourth quarter. It was the first time in 28 years that the Browns had won a season opener away from home.
There were also wins for the Baltimore Ravens, Washington Commanders, and Philadelphia Eagles.
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