Concerns about the ethics and safety of the procedure were raised when a baby was born with three parents.
The mother's nuclear DNA was removed from the donor egg during the experiment. The egg was fertilized with the husband's sperm.
There is a rare neurological disease called Leigh syndrome, which can be passed down through the maternal mitochondria.
The concern was that the maternal mitochondria would cause health problems for the child.
The mother's nuclear DNA is taken from an egg.
A study looking at the effects of this procedure on the genetics of individual cells five days after fertilization shows that they are not different from a control group.
Dozens of cells at the blastocyst stage of development were examined using a single-cell triple omics Sequencing method.
The authors report that their results show that spindle transfer is generally safe for embryo development.
The co-author of the study is an gynecologist at the ChinesePLA General Hospital in Beijing. We want to give a foundation for the development of the technique.
The study was unique and wonderful due to its high-quality data, according to a stem-cell biologist.
He said that the study was the first to compare human embryos that were created with the method.
Seven months after birth, the first child conceived using donor mitochondria and the spindle transfer method did not have any health issues, but the long-term effects are not yet known.
The nucleus may prefer cells with maternal mitochondria because they have been coexisting for a long time.
Studies have shown that the transfer works. The long-term health of children born using the therapy will need to be investigated.
Less than 5 percent of the maternal mtDNA was transferred in the 2016 case. Current techniques can cut that in half.
Mitochondrial donation is legal in the UK and Australia. It is banned in the US but not in China.
One in 5,000 children are affected byLeigh syndrome, a disease caused by pathological variations in maternal mitochondria.
Children with Leigh syndrome don't live past their 3rd birthday. Respiratory difficulties, vomiting, and failure to thrive are some of the problems they experience.
The nucleus of the human egg and sperm is what makes up most of the human embryo's genetic material. Mitochondria are the powerhouses of the cell. There are thousands of genes in the nucleus and small number in the mitochondria.
The mother's mitochondria are the only ones left to reproduce after the sperm is destroyed.
The paper was published in a scientific journal.
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