After the match, he expressed his emotions, giving him a four set victory over Nadal. It was 0: 53.
The 22-time major champion had a 22-match winning streak at Grand Slam tournaments ended by the 19-year-old.
After shaking hands with Nadal, the man buried his head in his hands and cried. As Nadal waved to the crowd, he buried his head in a towel on the bench.
The youngest American man to reach the quarterfinals at the US Open since Andy Roddick in 2006 is 24 years old, and he's by far the youngest male. He has two major quarterfinals of his career.
In the first half of the year, Nadal won the Australian Open and the French Open. He made it to the semifinals at Wimbledon before pulling out because of a torn abdominal muscle, which doesn't count as a loss.
Entering Monday's match, Nadal had won 27 in a row against Americans, the longest winning streak in majors against them.
Marin Cilic is still in the men's draw. It will be only the third time in the Open Era that a men's major tournament has a quarterfinals lineup without an ex-champion if he loses to Carlos Alcaraz on Monday.
Rublev advanced to the quarterfinals by beating No. 7 Cam Norrie. Rublev has never made it past the second round at New York and is 0-5 at all major tournaments.
The AP contributed to the story.