Gregg Semenza

The four papers that were withdrawn from the PNAS were written by a researcher who won a prize.

The work done by Semenza is one of the most important studies on the regulation of oxygen in the human body. In October 2020 there was a report about potential image duplications and other manipulation in Semenza's work.

Yesterday, four papers were withdrawn.

There is a representation notice.

We are retracting this article due to concerns with Figure 5. In Figure 5A, there is a concern that the first and second lanes of the HIF-2α panel show the same data, and that the first and second lanes of the HIF-1α panel show the same data, despite all being labeled as unique data. In Figure 5D, there is a concern that the second and third lanes of the HIF-1β panel show the same data despite being labeled as unique data. We believe that the overall conclusions of the paper remain valid, but we are retracting the work due to these underlying concerns about the figure. Confirmatory experimentation has now been performed and the results can be found in a preprint article posted on bioRxiv, ‘Homeostatic responses to hypoxia by the carotid body and adrenal medulla are based on mutual antagonism between HIF-1α and HIF-2α’ ( We apologize for the inconvenience.

The papers have been cited hundreds of times. Semenza was the principal investigator on more than nine million dollars in grants.

"Francis" tells Retractionwatch.

I saw problematic Gregg Semenza publications before his Nobel Prize.

I recognised his name when he got his Nobel Prize and went back for a second look.

Had I got him wrong?

No, there were more problematic publications.

One of the papers Semenza co-authored was written by the vice provost for research atHopkins.

Semenza has not responded to a request for comment. In the year 2020, we wrote about four such cases, and in the year 2019, we wrote about one. Daniel Kahneman didn't back down from his claims, but did walk back some of them.

It is Semenza's second retraction. A paper he co-authored was withdrawn in 2011.

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A Caltech researcher who shared the 2018?nobel prize in chemistry has withdrawn a paper after being unable to reproduce the results. She won half of the prize for her work on the evolution of genes.

There is a chemistrys retraction.

Readers of Retraction Watch may have heard about the pledge by Randy Schekman to boycott Cell, Nature, and Science due to the damage they do to science. The bully pulpit of the Nobles has been used to spark a discussion about science.

"Pnas retractions"

It is possible for a researcher to spot problems in a paper and cause a retraction. Things might move more quickly if it's a winner of the prize. The paper in the Proceedings of the National Academy of Sciences was withdrawn.

There is a chemistrys retraction.