Kelly, who scored the winner against Germany in the final of Euro 2022, has been ruled out of England's first squad.
Fran Kirby is also injured and manager SarinaWiegman is without two of her best friends.
The squad has two new players in Jordan Nobbs and Ebon Salmon.
The goalkeeper has been left out.
Sandy MacIver, the goalkeeper from Manchester City, and the captain of Manchester United, as well as Lauren James, were called up to the squad.
England will play Austria and Luxembourg in their final World Cup qualification games on 3 and 6 September.
The Lionesses will host a friendly against the USA at Wembley on October 7th if they beat Luxembourg or Austria in their next two games.
Tickets for the fixture between the Euro 2022 winners and the World Cup holders sold out in less than 24 hours.
If England are involved in the two-legged World Cup play-offs in October, tickets can be returned or exchanged for the home leg, and the USA game will be rearranged.
There will be more to come.