Aging the young before their time may not be as far off as some people think.
Young mice were injected with the blood of older mice in a new experiment. Human cells were immersed in older people's blood.
The young mice were given a blood donation from an older one. The younger mice were tested to see if the old blood caused tissue aging.
Compared to a control group, the mice that received blood from an older mouse had less twitch force and less relaxation during contraction.
The mice were put through a treadmill test seven days after the blood injection. Ice that refused to run were kept running until they ran out of gas.
The mice that received old blood ran a shorter distance on the treadmill.
The mice had markers for damage to the kidneys.
In this experiment, when older mice were given younger blood, they showed signs of decline.
A study done by the University of California in 2005 showed that creating conjoined twins of young and old mice can reverse the signs of aging in the old mice.
The researchers say that they have reported a transfer of senescence from old to young mice. The response is related to chronological age.
The researchers theorize that cells from older mice were promoting aging, like muscle weakness, loss of endurance, and tissue damage.
Even without chronological aging occurring first, senescent cells could affect nearby cells inside a younger person.
Within six days of the experiment, the researchers found a number of markers of aging in the blood of people between the ages of 60 and 70. When the experiment was repeated, these markers were not found.
According to the researchers, adjusting and changing various factors, including SASP, could lead to new therapeutic strategies for having a longer life.
The research was published in a scientific journal.
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