It is the first time that a pathway that begins in the gut and ends in the brain has been reported in research. A simple way to prevent it is reported by them. The results are published in a journal.
"LPSs in general are probably the most potent pro- inflammatory neurotoxic glycolipids known," says Dr. Different forms ofLPS have been detected in the brains of people with Alzheimer's disease.
The pathway from the gut to the brain is detailed in this study. There is a leak out of the GI tract and a crossing of the blood brain barrier. It increases inflammation in brain cells and reduces the amount of light entering the cells. In AD- affected neurons, a deficit of thisProtein leads to cell death. Adequate intake of fiber can head off the process, according to them.
Threefold are the novel features of this pathway. The AD-stimulating pathway is very local and active throughout our lives. The by-product of GI-tract-based metabolism is the potent neurotoxin BF-LPS. The source of the neurotoxin BF-LPS can be regulated by diet.
"Dietary-based approaches to balance the microorganisms in the microbiome may be an attractive means to modify the abundance, speciation, and complexity of enterotoxigenic forms of AD-relevant microbes."
An improved understanding of the interaction between the GI tract-Central Nervous System axis and the GI-tract microbiome could lead to new diagnostic and therapeutic strategies for Alzheimer's disease.
Americans eat around 15 grams of fiber a day, according to estimates. 25 grams a day is recommended for women and 38 grams for men by the US Department of Agriculture. Women and men should eat 21 and 30 grams per day over 50.
Alzheimer's disease is the most common diagnosis for patients with dementia and the sixth leading cause of death. According to experts, 5.8 million Americans 65 and older have Alzheimer's disease, and the prevalence in the United States is projected to increase to almost 14 million by the year 2050.
The LSU Health New Orleans co- authors were Drs. Sharfman and Jaber. A co-author was Aileen Pogue from Al Chem.
Funding for the research came from LSU Health New Orleans, the Brown Foundation, and the National Institute on Aging.
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