The fifth season of Rick and Morty focused on how evil some of their multiversal counterparts could be, but it also brought the grandfather and grandson team closer together to show how they have matured as people. The new season 6 trailer doesn't directly touch on any of the series' dangling plot lines, but it suggests that the entire Smith family is going to become more involved in Rick.
After years of wanting more chances to mix it up with aliens from other worlds, Rick's granddaughter Summer is finally getting what she wants and realizing that it really isn't all that great. Summer isn't much of a John McClane type, but her mother Beth and her clone, Space Beth, are more prepared to deal with the madness their father brings into their lives.
The fact that Rick is on the run from a lot of people who want him dead suggests that the new season will have a complicated plot to rid the universe of his nemesis. Rick and Morty's sixth season may be about the sheer number of people who still have it out for the old man now that he's tighter with his family.
The sixth season of Rick and Morty will premiere on Adult Swim.