Rodriguez was hit on the hand by a pitch in the eighth and was removed from the game for a pinch hitter in the ninth.
Rodriguez was going to get X-rays, according to Scott Servais.
He wasn't comfortable with the bat in his hand. We will pray that it is not broken.
Rodriguez was hit on the back of the hand while swinging at a pitch. He played in the field in the bottom of the second but struck out in the top of the third.
Rodriguez had a 0-for-4 performance. He's batting.270 with 18 homers and 57 runs.
The pinch-hitter, who was pinch-hit for Rodriguez, delivered a go-ahead two-run single with two outs off Astros closer Ryan Pressly.
Pressly had converted 21 of his 24 saves this season. He gave up two runs on two hits, walked one and struck out two in the loss, his first blown save since June 23, when he was with the New York Yankees.
He said his familiarity with Pressly gave him an advantage.
He knows that Pressly likes to attack the zone. I was already hitting.
Since we traded him over there, he's been a thorn in our side. He got a big hit.
Moore left the game with back pain.
Seattle beat Houston for the first time since June 8.
The AP contributed.