There is a noticeable difference between freshman year and Captain America: Civil War. Rather than returning to his apartment to see Tony Stark in his home, it is Norman Osborn who is talking to his Aunt May when he walks through the door. Peter having Norman as his mentor ends his life in an unexpected trajectory that collides him with many unexpected characters in the universe according to Brad Winterbaum.
The big hook of the new show is "What If...Norman Osborn was Peter Parker's surrogate dad?" and that puts Pete on a collision course with characters that the MCU hasn't staked a firm claim to yet. There was footage of Peter's allies, from Norman's son to Amadeus Cho. Cho was portrayed as a scientific rival to Peter in the Ultimate Spider-Man cartoon before he became the Iron Spider. Minoru, best associated with the Runaways, has no real connection to Spider-Man, but he is included in the roster for 2K's upcoming game.
There is a mystery as to how Freshman Year fits into the Multiverse Saga. It isn't a bad thing to have a few universes get figured out ahead of the movie. The first season of Spider-Man: Freshman Year will hit Disney+ in four years, so whether this new Spider-Man cartoon will do more than fill the box will have to wait.
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