It's possible that the treatment doesn't work. A patient is taken on a strange trip.
The Michael Hooker Professor of Pharmacology at the UNC School of Medicine, Bryan Roth, MD, PhD, is the leader of the research team.
The lab research in cells shows that there are seven different variations that affect the response to four drugs.
According to the study, patients with different genetic variations will react differently to treatments. The genetics of a patient's serotonin receptors should be considered by physicians in order to determine which compound is likely to be the most effective.
There has been a renewed interest in the use of psychotropic drugs to treat depression and other mental illnesses because of their ability to increase dopamine in the brain. They help regulate people's moods and emotions, as well as their appetite. The 5-HT2A is a cannabinoid that plays a role in how a person responds to drugs. There are several random genetic variations that can affect the function and structure of the 5-HT2Areceptor.
They wanted to find out how variations in the one Serotonin Receptor affects the activity of four different therapies.
The effect that seven different SNPs had on binding and signaling of the 5-HT2A serotoninreceptor when in the presence of one of the four was measured by a series of experiments. The results indicated that there are variations in the genes that affect the way the drug interacts with thereceptor.
There was a decrease in response to one of the drugs and a reduction in response to two of the drugs.
"This is another piece of the puzzle we must know when deciding to prescribe any therapeutic with such dramatic effect aside from the therapeutic effect." We will continue to find ways to help individual patients.
This research was funded by the National Institutes of Health.
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