There are newer drugs that require injections twice a month. Braunwald wondered what would happen if these drugs were given widely as a public health intervention. If you start giving it at age 30 you will live to 100.
The drugs aren't used as much as they could. Insurers don't pay because they are still inconvenient and costly. Gene editing is the biggest stick because it is done. Braunwald says you don't have to return. Atherosclerotic cardiovascular disease is the most common cause of death in the industrialized world, and the main cause is low density lipoproteins.
40 people with an inherited form of high cholesterol will be treated in New Zealand with Verve. Children with FH can have higher cholesterol readings than the average person. Many people only learn they have a problem when they have a heart attack.
The use of base editing in humans is the first of its kind. Base editing works by substituting a single letter of DNA for another.
PCSK9 is a genes that is being edited. The company says it will turn the genes off by introducing a one-letter spelling.
After his brother died of a heart attack, he started Verve.
The base-editing technique is moving fast because it is similar to the vaccine for covid-19 The treatment is similar to the vaccines in that it involves genetic instructions wrapped in a nanoparticles.
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