The most comprehensive atlas of genetic data on zebrafish has been published.
Researchers will be able to study conditions from different types of cancer with the help of the atlas. More researchers may be able to replace mammal models in their studies.
A nationwide team of 27 laboratories collaborated to catalog published open-access datasets. The effort resulted in a lot of genes being regulated in the fish.
The broadest picture of candidate DNA regions for genetic research into development and diseases can be found in the study looking at the second most-used animal model.
The paper, which appeared in Nature Genetics today, details how genes are involved in several stages of development.
The professor who led the study was from the University ofBirmingham.
It is a significant breakthrough that could underpin some of the most exciting medical and life sciences developments for years to come.
Over 50 researchers around the world have been coordinated by Professor Boris Lenhard from Imperial College London. The result of a bottom-up initiative for collaborating across borders is a testament to how impact can be achieved. Researchers can use the genetic information in the catalog to conduct future studies.
Zebrafish are an excellent model for research. They are ideal candidates for studying diseases and disorders because they are transparent as embryos. The properties have given researchers insight into the human condition.
We are one step closer to having a fully realized map from which to add the human genome with our new catalog. Novel treatments, drugs, and a better understanding of the human and animal disease will be possible thanks to this type of activity.
The data integration was led by the Associate Professor and Group Leader of the Department of Biosciences and Nutrition.
The study consolidates all individual datasets into one framework allowing researchers across the world to address questions which could not be addressed by the individual studies.
More information: Carsten Daub, Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements, Nature Genetics (2022). DOI: 10.1038/s41588-022-01089-w. www.nature.com/articles/s41588-022-01089-w Journal information: Nature Genetics
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