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The development of a human embryo

A human embryo is developed.

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Scientists are starting to understand why about two-thirds of embryo creation stops growing.

The discovery gives us some clues as to how the embryo will develop. Around 1 in 4 treatment rounds leads to pregnancies in Europe, so this could lead to higher success rates.

Several eggs are placed in a dish with sperm and checked regularly through a microscope to see which ones have been fertilised and lead to an embryo.

A ball of 100 cells can be transferred into a woman's uterus. 6 in 10 embryos never make it to the blastocyst stage Three days after fertilisation, they stop developing when they have only a few cells.

Andrew Hutchins is a professor at the Southern University of Science and Technology in Shenzhen.

Hutchins and his team were able to learn more by analyzing the strands of genetic material that showed which genes were active. A template is used for the production of an RNA molecule. Instructions for making aProtein are provided by theRNA. The team looked at the arrested embryo's chromosomes.

The researchers compared the whole set with existing work on embryos that seemed to be developing normally, after combining this with data on six other arrested embryos.

They were surprised to find that the arrested embryos had lower rates of chromosomal abnormality than the healthy ones.

They found that the arrested embryos could be split into three groups. A crucial step in the embryo's development is when it fails to start making its own genes from its own mother's genes.

The arrest of type 2 and 3 embryos fail to make a transition in how they get energy. The metabolism of healthy embryos is dependent on the amount of oxygen they get. Oxygen levels in the embryo are low when it is in the uterus and before the birth of the baby.

In type 2 arrested embryos, their oxygen- dependent metabolism continues, while in type 3 it falls to low levels, with neither correctly moving to a non-oxygen dependent metabolism.

Hutchins and his team tried to treat a group of arrested embryos with compounds found in red wine. He says that they will force the cells to change their metabolism.

About half of the 42 arrested embryos had Resveratrol in their system. Only three of them reached the blastocyst stage. Hutchins said that even these didn't seem to have normal genes. Even though they don't want to, we're forcing them to develop.

The embryos were allowed to stay at the arrest stage for too long, which may have caused the abnormal genes to occur.

A reduction in the number of embryos that arrest in the first place is one of the findings. She says that it could increase the number of embryos a couple can have for a baby. They found something fascinating.

The journal's title is "pbio.3001682."

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